Desde 07 de março de 2010 é sabido que a “Vitamina D3 controla a sinalização do receptor do antígeno das células T e a ativação das células T humanas” * “Vitamin D controls T cell antigen receptor signaling and activation of human T cells | Nature Immunology”

 

“Phospholipase C (PLC) isozymes are key signaling proteins downstream of many extracellular stimuli. Here we show that naive human T cells had very low expression of PLC-γ1 and that this correlated with low T cell antigen receptor (TCR) responsiveness in naive T cells. However, TCR triggering led to an upregulation of 75-fold in PLC-γ1 expression, which correlated with greater TCR responsiveness. Induction of PLC-γ1 was dependent on vitamin D and expression of the vitamin D receptor (VDR). Naive T cells did not express VDR, but VDR expression was induced by TCR signaling via the alternative mitogen-activated protein kinase p38 pathway. Thus, initial TCR signaling via p38 leads to successive induction of VDR and PLC-γ1, which are required for subsequent classical TCR signaling and T cell activation.”

 

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Fonte: Vitamin D controls T cell antigen receptor signaling and activation of human T cells | Nature Immunology

 

Com a colaboração de Gustavo Bueno Bellini