Bibliografia Científica, Coronavíruss, Covid - 19, Direito à Saúde e à vida, Endocrine Society dos EUA, hormônio esteroide, Imunidade Inata, Imunologia, Projeto Genoma Humano e as doenças autoimunes, Resolução CFM n° 1098, de 30 de Junho de 1983, Saúde Pública, Vitamina D3
por Celso Galli Coimbra

UMA ÚNICA GRANDE DOSE DE VITAMINA D PODE SER USADA COMO MEIO DE PREVENÇÃO E TRATAMENTO DA DOENÇA CORONAVIRUS 2019 * A Single Large Dose of Vitamin D Could be Used as a Means of Coronavirus Disease 2019 Prevention and Treatment | Drug Design, Development and Therapy

UMA ÚNICA GRANDE DOSE DE VITAMINA D PODE SER USADA COMO MEIO DE PREVENÇÃO E TRATAMENTO DA DOENÇA CORONAVIRUS 2019

A Single Large Dose of Vitamin D Could be Used as
a Means of Coronavirus Disease 2019 Prevention
and Treatment

“(…) Vitamin D Administration is Convenient and
Safe“


“(…) Vitamin D is a lipid-soluble vitamin, and can be administered
as a draught. From our clinical experience in patients with Vit D deficiency or insufficiency, a single dose of 300,000 IU (in one ampulla) is safe. Four weeks after the administration, the serum 25(OH)D concentration can be elevated to the level of about 60 ng/mL, and all the patients have normal blood calcium levels. Vit D supplementation is very safe and Vit D toxicity is a rare event caused by ingestion of excessively high
amounts of Vit D. Most studies in children and adults have suggested that the blood levels need to be above 150 ng/mL before there is any concern. Therefore, an upper level of 100 ng/mL provides a safety margin in reducing risk of hypercalcemia. [12] The cases of Vit D toxicity accompanied by various toxic symptoms have serum 25(OH)D concentrations ranging from 213 to >640 ng/mL (533 to >1600 nmol/L).[36] To ensure safety, testing the blood calcium and 25(OH) D levels two to four weeks after taking Vit D is needed, but in most cases it is not always necessary. (…)”

Department of Endocrinology and
Metabolism, Peking University Third
Hospital, Beijing 100191, People’s
Republic of China

This article was published in the following Dove Press journal:
Drug Design, Development and Therapy – BIBLIOGRAFIA NO FINAL

07.04.2021: Revista “Frontiers in Immunology” (Fronteiras em Imunologia” – a sétima revista mais citada entre as de acesso livre e a primeira mais citada na área de imunologia) – Tradução pública POR CERTIDÃO para o português de sua Publicação científica de abril de 2021 de médicos e Pesquisadores alemães sobre o “protocolo Coimbra”: “Resistência à Vitamina D como uma Possível Causa de Doenças Autoimunes: Uma Hipótese Confirmada feita por um Protocolo de Alta dosagem de Vitamina D Terapêutica” * “Vitamin D Resistance as a Possible Cause of Autoimmune Diseases: A Hypothesis Confirmed by a Therapeutic High-Dose Vitamin D Protocol”

30.04.2021: “Proteína ‘pico’ distinta da SARS-CoV-2 desempenha um papel fundamental na própria doença, mostra estudo” * “O artigo, publicado em 30 de abril de 2021, na Circulation Research, também mostra conclusivamente que COVID-19 é uma doença vascular, demonstrando exatamente como o vírus SARS-CoV-2 danifica e ataca o sistema vascular em nível celular.” * “SARS-CoV-2’s distinctive ‘spike’ protein plays a key role in the disease itself, shows study” – News-Medical

Posted May 27, 2021: “Sensibilidade reduzida da variante B.1.617.2 do SARS-CoV-2 infecciosa a anticorpos monoclonais e soros de indivíduos convalescentes e vacinados” – “O soro de indivíduos que receberam uma dose de AstraZeneca Vaxzevria quase não inibiu B.1.617.2. Assim, a propagação de B.1.617.2 está associada a um escape para anticorpos que alvejam epítopos não RBD e RBD Spike.”  * “Reduced sensitivity of infectious SARS-CoV-2 variant B.1.617.2 to monoclonal antibodies and sera from convalescent and vaccinated individuals” * | bioRxiv 

“A vitamina D protege contra o coronavírus” * “La vitamina D protegge dal coronavirus” – “Simplificando, um sistema imunológico que tem vitamina D suficiente reage mais rápida e eficazmente aos vírus, reduzindo o risco de infecção. Se o vírus consegue infectar o corpo, a vitamina D garante que a gravidade da inflamação seja mantida dentro dos limites. Em conclusão, pode-se dizer que “Valores reduzidos de vitamina D determinaram um maior risco de infecção, mortalidade e gravidade da infecção por COVID-19” e que “a suplementação pode ser considerada uma medida preventiva e terapêutica”.

“Breve relatório: Deficiência de vitamina D em SARS-CoV-2 induzida por ARDS” * “Brief Report: Vitamin D deficiency in SARS-CoV-2-induced ARDS” * “Os níveis de vitamina D estão inversamente associados às síndromes virais respiratórias superiores clinicamente aparentes, bem como à ARDS, devido aos seus efeitos na modulação da resposta imune. A vitamina D foi estabelecida como moderando a inflamação, promovendo a atividade das células T reguladoras, aumentando a liberação de IL-10 e inibindo a liberação de interleucina-6 (IL-6) de subconjuntos de células inflamatórias.”

27.04.2021: “Vitamina D oral e tópica, luz solar e fototerapia UVB Controle com segurança a psoríase em pacientes com concentrações normais de 25-hidroxivitamina D no soro de pré-tratamento: uma revisão da literatura e discussão das implicações para a saúde” * “Oral and Topical Vitamin D, Sunshine, and UVB Phototherapy Safely Control Psoriasis in Patients with Normal Pretreatment Serum 25-Hydroxyvitamin D Concentrations: A Literature Review and Discussion of Health Implications”  Nutrients | Free Full-Text |

“Vitamina D oral e tópica, luz do sol e fototerapia UVB Controle com segurança a psoríase em pacientes com concentrações normais de 25-hidroxivitamina D no soro de pré-tratamento: uma revisão da literatura e discussão das implicações para a saúde” * “Oral and Topical Vitamin D, Sunshine, and UVB Phototherapy Safely Control Psoriasis in Patients with Normal Pretreatment Serum 25-hydroxyvitamin D Concentrations: A Literature Review and Discussion of Health Implications” | Preprints

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