A importância dos níveis de vitamina D nas doenças autoimunes – Bras J Rheumatol 2010; 50 [1]:67-80

“A vitamina D e seus pró-hormônios têm sido alvo de um número crescente de pesquisas nos últimos anos, demonstrando sua
função além do metabolismo do cálcio e da formação óssea,
incluindo sua interação com o sistema imunológico, o que
não é uma surpresa, tendo em vista a expressão do receptor de
vitamina D em uma ampla variedade de tecidos corporais como
cérebro, coração, pele, intestino, gônadas, próstata, mamas
e células imunológicas, além de ossos, rins e paratireoides.1
Estudos atuais têm relacionado a deficiência de vitamina
D com várias doenças autoimunes, incluindo diabetes melito
insulino-dependente (DMID), esclerose múltipla (EM), doença
inflamatória intestinal (DII), lúpus eritematoso sistêmico (LES)
e artrite reumatoide (AR).1-4 Diante dessas associações, sugere-
-se que a vitamina D seja um fator extrínseco capaz de afetar
a prevalência de doenças autoimunes.5”

(…)

 

“VITAMINA D E DOENÇAS AUTOIMUNES

“De maneira geral, o efeito da vitamina D no sistema imunológico se traduz em aumento da imunidade inata associado a uma
regulação multifacetada da imunidade adquirida.22 Tem sido
demonstrada uma relação entre a deficiência de vitamina D e
a prevalência de algumas doenças autoimunes como DMID,
EM, AR, LES e DII.5,13

“Sugere-se que a vitamina D e seus análogos não só previnam o desenvolvimento de doenças autoimunes como também
poderiam ser utilizados no seu tratamento.11 A suplementação
de vitamina D tem-se mostrado terapeuticamente efetiva em
vários modelos animais experimentais, como encefalomielite
alérgica, artrite induzida por colágeno, diabetes melito tipo 1,
doença inflamatória intestinal, tireoidite autoimune e LES.8
Baixos níveis séricos de vitamina D podem, ainda, estar relacionados com outros fatores como diminuição da capacidade
física, menor exposição ao sol, maior frequência de polimorfismos nos genes do RVD, efeito colateral de medicamentos,
além de fatores nutricionais.10,11”

(…)

 

CONTINUA EM:

Fonte:  A importância dos níveis de vitamina D nas doenças autoimunes – Bras J Rheumatol 2010; 50 [1]:67-80

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